 Description of RTD activities MSci thesis: complay results from diferent investigations of the representatives of the genus Teucrium (T. polium; T.montanum; T. scordium; T. chamaedrys) in Macedonia that includes :
• Horological and ethnofarmagological investigations
• Phytochemical investigation of the flavonoids:
o Extractions and HPLC;GC-MS qualitative and quantitative analysis;
o Separation, isolation (semipreparative HPLC), structural characterisation and identification (NMR; GC-MS) of unknown flavonoid compound;
o Distribution and localisation of the flavonoids in the plants
o Season variability of flavonoid compounds
• Chemotaxonomical analysis
• Bioactivity of dry extracts from T. polium
o Pharmacological investigations-in vivo experimental design for assesment of:
hypoglycemic effects,
antihiperglycemic effects,
hypolipidemic effects
• evaulated in normal and streptozotocin-hyperglycemic rats,
• single and multiple dose,
• acute and subchronic treatment
• intraperitoneal and intragastral administration,
• comparation with Glibenclamide (widely used oral antidiabetic)
o Toxicological investigations:
biochemical assesment of AST, ALP, ALT, LDH, CPK, Urea, Creatinin, Total proteins, Albumins, Na, K as bioindicators of the funcion of the kidneys, hart, and hepar
histomorphological assesment of kidneys, hart, lungs and hepar
Experiences in international Programmes Chair of Working group for Medicinal and aromatic plants-SEEDnet project
National coordinator for Medicinal and aromatic plants in ECPGR
Inserted / Updated 2007-09-07 / 2007-09-07 |
