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Rudjer Boskovic Institute
Division of Molecular Medicine

 Contact data
StreetBijenicka c. 54 
ZIP, City, State 10000 - Zagreb (Croatia) 
Phone+385 1 456 0964 
Fax+385 1 4561010 
 Contact person

Prof. dr. sc. Mira Grdisa (Senior Investigator)
 Employees in RTD
> 100
 Activities in Research and Development

 RTD sectors:
» Bio technology     
» Medicine and Health     

 Area of expertise (keywords)
» cell cycle regulation
» proliferation
» diferentiation
» apoptosis
» cancer treatment
» drug delivery
» TAT technology
» regulation of gene and protein expression
» signal transduction pathways
 RTD Experiences

 RTD focus of organization
Specific targeted therapy of tumors, delivery of drugs into the cells, signal transduction pathways in proliferation and apoptosis

 Description of RTD activities
Research and Professional Experience:
- TAT-technology - Cell cycle regulation - apoptosis (B-CLL)
- Differentiation and maturation of red blood cells, biochemical and molecular biology aspects
- Expression of proteins and genes during differentiation
- Regulation of expression (methylation, second messengers)
- Antitumor effect, mechanism of action of different substances, for potential antitumor drugs
- Tumor suppressor genes
- Study of signal transduction pathways
- In vitro technology
- Enzymology and protein chemistry
- Auxiliary techniques: isolation DNA and RNA, Northern and Southern blotting, Run-on assay, work with labeled compounds, receptor-ligand assays, membrane transport assays, cell culture work, standard microbiological methods, isolation and characterization of proteins (gel filtration, ion exchange and affinity chromatography, isoelectric focusing, FPLC, PAGE, Western blotting, immunoprecipitation), characterization of enzymes, kinetic measurements.

 Experiences in international Programmes
1995-1998 COST 862 “Ruminants Mycoplasmes”, adjoin project founded by European Economic Community (collaborator)
2005 –2006 “Cogito” project in collaboration with French Gouverment “Involvment of the ESCRT machinery in TfR sorting towards HD3 exosomes.” (main researcher)

 Inserted / Updated
2008-03-31 / 2010-04-19